The first U.S. power module on International Space Station (ISS) was activated in December 2000. Comprised of solar arrays, nickel-hydrogen (NiH2) batteries, and a direct current power management and distribution (PMAD) system, the electric power system (EPS) supplies power to housekeeping and user electrical loads. Modeling EPS performance is needed for several reasons, but primarily to assess near-term planned and off-nominal operations and because the EPS configuration changes over the life of the ISS. The System Power Analysis for Capability Evaluation (SPACE) computer code is used to assess the ISS EPS performance. This paper describes the process of validating the SPACE EPS model via ISS on-orbit telemetry. To accomplish this goal, telemetry was first used to correct assumptions and component models in SPACE. Then on-orbit data was directly input to SPACE to facilitate comparing model predictions to telemetry. It will be shown that SPACE accurately predicts on-orbit component and system performance. For example, battery state-of-charge was predicted to within 0.6 percentage points over a 0 to 100 percent scale and solar array current was predicted to within a root mean square (RMS) error of 5.1 Amps out of a typical maximum of 220 Amps. First, SPACE model predictions are compared to telemetry for the ISS EPS components: solar arrays, NiH2 batteries, and the PMAD system. Second, SPACE predictions for the overall performance of the ISS EPS are compared to telemetry and again demonstrate model accuracy.